Mast Cell Activation Syndrome (MCAS) treatments can use medications such as:
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Antihistamines: Non-sedating, second-generation antihistamines like cetirizine, loratadine, or fexofenadine are commonly used to block the effects of histamine and manage symptoms such as itching, flushing, and hives.
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Mast Cell Stabilizers: Medications like cromolyn sodium or ketotifen can help stabilize mast cells and reduce their reactivity.
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Leukotriene Modifiers: Montelukast is a leukotriene receptor antagonist that may be prescribed to manage respiratory and other symptoms.
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Proton Pump Inhibitors (PPIs): Omeprazole can help manage gastrointestinal symptoms by reducing stomach acid production.
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Adrenaline Auto-Injector: Individuals with MCAS who are at risk of severe allergic reactions, including anaphylaxis, may be prescribed an adrenaline auto-injector and trained on how to use it in case of an emergency.
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Mast Cell Stabilizing Medications: In more severe cases of MCAS, medications like tyrosine kinase inhibitors (e.g. imatinib) or anti-IgE therapy (e.g. omalizumab) may be considered to manage symptoms and mast cell activation.