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Question: does pbmm2 modify MM and ML tags for supplementary alignments with hard clippings? #621

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lh3 opened this issue Nov 17, 2023 · 2 comments
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@lh3
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lh3 commented Nov 17, 2023

@armintoepfer, here is a pbmm2 question for you. PacBio now outputs MM/ML tags for methylation. When pbmm2 outputs a supplementary alignment with hard clippings, does it modify the original MM/ML, copy them over to the output SAM line, or discard MM/ML on hard clipped SAM line? For the context, see samtools/hts-specs#646, but you don't have to read the thread.

@armintoepfer
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Hey @lh3, pbmm2 never hard clips. All of our alignments are either primary or supplementary with soft clippings.

@armintoepfer armintoepfer self-assigned this Nov 20, 2023
@lh3
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lh3 commented Nov 20, 2023

Got it. Thanks!

@lh3 lh3 closed this as completed Nov 20, 2023
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