gnomad update

[cheanney]

Hi,

The gnomad v4 is out. Any plans on updating this source?

Thanks,

Anney

[kmoad]

We do plan to update to v4. It's more complicated than a typical annotator because the size of gnomad4 does not work with our model of distributing annotator data to user machines. Arguably, gnomad3 and some other full-genome annotators were already too large.

We are working on a version of gnomad that supports querying remote data sources, probably using the hail tables. Doing this performantly is driving some changes in our annotator architecture.