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CITATION.cff
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# This CITATION.cff file was generated with cffinit.
# Visit https://bit.ly/cffinit to generate yours today!
cff-version: 1.2.0
title: >-
Computational synthesis of cortical dendritic
morphologies.
message: >-
If you use this software, please cite it using the
metadata from this file.
type: software
authors:
- family-names: Kanari
given-names: Lida
orcid: 'https://orcid.org/0000-0002-9539-5070'
- family-names: Dictus
given-names: Hugo
- family-names: Chalimourda
given-names: Athanassia
- family-names: Van Geit
given-names: Werner
orcid: 'https://orcid.org/0000-0002-2915-720X'
- family-names: Coste
given-names: Benoit
- family-names: Shillcock
given-names: Julian
orcid: 'https://orcid.org/0000-0002-7885-735X'
- given-names: Kathryn
family-names: Hess
orcid: 'https://orcid.org/0000-0003-2788-9754'
- family-names: Markram
given-names: Henry
orcid: 'https://orcid.org/0000-0001-6164-2590'
- family-names: Arnaudon
given-names: Alexis
orcid: 'https://orcid.org/0000-0001-9486-1458'
identifiers:
- type: doi
value: 10.1016/j.celrep.2022.110586
description: The DOI of the related article.
repository-code: 'https://github.com/BlueBrain/NeuroTS'
abstract: >-
Neuronal morphologies provide the foundation for the electrical behavior of
neurons, the connectomes they form, and the dynamical properties of the brain.
Comprehensive neuron models are essential for defining cell types, discerning
their functional roles, and investigating brain-disease-related dendritic
alterations. However, a lack of understanding of the principles underlying
neuron morphologies has hindered attempts to computationally synthesize
morphologies for decades. We introduce a synthesis algorithm based on a
topological descriptor of neurons, which enables the rapid digital
reconstruction of entire brain regions from few reference cells. This
topology-guided synthesis generates dendrites that are statistically similar to
biological reconstructions in terms of morpho-electrical and connectivity
properties and offers a significant opportunity to investigate the links between
neuronal morphology and brain function across different spatiotemporal scales.
Synthesized cortical networks based on structurally altered dendrites associated
with diverse brain pathologies revealed principles linking branching properties
to the structure of large-scale
networks.
keywords:
- Dendritic morphology
- Topological synthesis
- Artificial neuron
- Topological Morphology Descriptor
- Morphological synthesis
license: GPL-3.0