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LINCS2020.md

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DrugAI

LINCS2020 Download

  1. Data are download from LINCS2020.
  • This data bundle is an expansion to the LINCS2017
  • Only compound data are downloaded. other data types are including:
    • oe: overexperssion
    • sh: knockdown
    • crispr: xpr
    • misc:
  1. Gene Infer weights (landmark genes conversion matrix to 11350 genes) could be download from GEO:GSE92743
  • GSE92743_Broad_OLS_WEIGHTS_n979x11350.gctx
  1. repurposing_drugs from here

  2. For this project, we only download compound data

  • GCTx: download contrl and treatment of level 3 data (trt_cp, ctr)
  • MetaData:
    • instinfo: level 3-4
    • siginfo: level 5
    • geneinfo
    • compoundinfo

Data Query

  • cmapPy: read GCTx
  • cmapBQ: query LINCS database using bigQUERY

Data Format

data mapping here

cmapBQ

GCTx data format

GCTx