mapping to a large genome

[awieeeee]

Dear yupenghe,

I would like to know to deal with organisms that have chromosomes more than 512Mb.
During mapping, samtools index command failed with showing the error message.
samtools index: failed to create index for "[sample].bam": Numerical result out of range

Thanks.

[yupenghe]

That should be fine. Methylpy works for human genome which is larger than 512Mb. Is the error reproducible? If so, having some files to reproduce the error will help me identify the issue.