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Consider adding CES1 / CES2 as enzymes #54

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egonw opened this issue Aug 25, 2014 · 3 comments
Open

Consider adding CES1 / CES2 as enzymes #54

egonw opened this issue Aug 25, 2014 · 3 comments

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@egonw
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egonw commented Aug 25, 2014

They are involved in the heroin metabolism:

http://wikipathways.org/index.php/Pathway:WP2645

And listed in this "opinion" as typically neglected but relevant for drug metabolism (and see refs at the bottom):

http://www.pharmacytimes.com/publications/issue/2013/December2013/Carboxylesterases-and-Drug-Interactions

@vedina vedina added this to the xmetdb-0.0.5 milestone Mar 3, 2015
@vedina
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vedina commented Mar 3, 2015

Could you confirm these are the correct UNIPROT links (or provide the correct ones)

CES1 http://www.uniprot.org/uniprot/P23141 or http://www.uniprot.org/uniprot/O46421
CES2 http://www.uniprot.org/uniprot/O00748

@egonw
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egonw commented Mar 3, 2015

@vedina
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vedina commented Mar 3, 2015

Thanks.
Do these have (do we want to specify) alleles?

vedina added a commit that referenced this issue Mar 3, 2015
Enzymes can also be added by the admin via the UI
@egonw egonw modified the milestones: xmetdb-2.0.0, xmetdb-1.0.0 Jun 17, 2015
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