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How can I perform domain clustering by foldseeek? #231

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WongQh opened this issue Jan 17, 2024 · 0 comments
Open

How can I perform domain clustering by foldseeek? #231

WongQh opened this issue Jan 17, 2024 · 0 comments

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@WongQh
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WongQh commented Jan 17, 2024

It might be a silly question but I still don‘t understand how you perform domain clustering by foldseek.
You mentioned in your nature article "Clustering predicted structures at the scale of the known protein universe"that " Clustering of the start and end positions for Foldseek hits of one protein against all others was used to define potential domain boundary positions. Each predicted domain region was linked to the others sharing structural similarities and graph-based clustering was used to define domain families and interdomain similarity. "
Is it performed by foldseek or other algrithm? How can I do it using my own data?

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