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<!DOCTYPE html>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<meta charset="utf-8">
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<title>Québec Main Models</title>
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<div id="quebec-registre-de-la-population-du-quebec-ancien-1630-1750-main-effects" class="section level1 tab-content">
<h1>Québec (Registre de la Population du Québec Ancien 1630-1750), main effects</h1>
<div id="loading-details" class="section level3 accordion">
<h3>Loading details</h3>
<div class="sourceCode"><pre class="sourceCode r"><code class="sourceCode r"><span class="kw">source</span>(<span class="st">"0__helpers.R"</span>)
opts_chunk$<span class="kw">set</span>(<span class="dt">warning=</span><span class="ot">TRUE</span>, <span class="dt">cache=</span>F,<span class="dt">tidy=</span><span class="ot">FALSE</span>,<span class="dt">dev=</span><span class="kw">c</span>(<span class="st">'png'</span>),<span class="dt">fig.width=</span><span class="dv">20</span>,<span class="dt">fig.height=</span><span class="fl">12.5</span>)
make_path =<span class="st"> </span>function(file) {
<span class="kw">get_coefficient_path</span>(file, <span class="st">"rpqa"</span>)
}
<span class="co"># options for each chunk calling knit_child</span>
opts_chunk$<span class="kw">set</span>(<span class="dt">warning=</span><span class="ot">FALSE</span>, <span class="dt">message =</span> <span class="ot">FALSE</span>, <span class="dt">echo =</span> <span class="ot">FALSE</span>)</code></pre></div>
</div>
<div id="analysis-description" class="section level2">
<h2>Analysis description</h2>
<div id="data-subset" class="section level3">
<h3>Data subset</h3>
<p>The <code>rpqa.1</code> dataset contains only those participants where paternal age is known and the birthdate is between 1630 and 1750.</p>
</div>
<div id="model-description" class="section level3">
<h3>Model description</h3>
<p>All of the following models have the following in common:</p>
<div id="estimation" class="section level4">
<h4>Estimation</h4>
<p>We fit all models using <code>brms</code> v. 1.2.0, a Bayesian regression analysis statistical package. <code>brms</code> uses <code>Stan</code>, a probabilistic programming langugage to fit models using Hamiltonian Monte Carlo.</p>
</div>
<div id="covariates" class="section level4">
<h4>Covariates</h4>
<p>We adjusted for average paternal age within families to isolate the effect of paternal age differences between siblings. We further adjusted for birth cohort in five-year groupings (small groupings at the edge of the range were lumped) to account for secular changes in mortality and fertility, as well as residual censoring. We adjusted for parental deaths in the first 45 years of life to remove effects related to orphanhood and parental senescence (in categories of 0-1, 2-5, 6-10, …, 45+, unknown) for both parents separately. Parental loss at 45+ served as the reference category. We adjusted for maternal age (up to 20, 21-34, 35+), which we binned to reduce multicollinearity with paternal age and to capture nonlinear effects. A maternal age of 21-34 served as the reference category. We also adjusted for number of siblings continuously, number of older siblings (0-5, 5+), and being born last. Being first-born served as the reference category.</p>
</div>
<div id="model-stratification" class="section level4">
<h4>Model stratification</h4>
<p>We added random intercepts for each family (father-mother dyad). We then controlled for the average paternal age in the family. Hence, the paternal age effects in the plot are split into those between families and those within families or between siblings. We are interested in the effect of paternal age between siblings, as this effect cannot be explained by e.g. genetic propensities of the father to reproduce late.</p>
</div>
<div id="priors" class="section level4">
<h4>Priors</h4>
<p>We used weakly informative priors that are documented in each model summary.</p>
</div>
</div>
</div>
<div id="m1_children_linear_noranef" class="section level2 tab-content">
<h2><em>m1</em>: No sibling comparison</h2>
<p>Here, we ignore the pedigree structure of the data to see whether it matters for the estimation of the paternal age effect.</p>
<div id="model-summary" class="section level3 tab-content">
<h3>Model summary</h3>
<div id="full-summary" class="section level4">
<h4>Full summary</h4>
<div class="sourceCode"><pre class="sourceCode r"><code class="sourceCode r">model_summary =<span class="st"> </span><span class="kw">summary</span>(model, <span class="dt">use_cache =</span> <span class="ot">FALSE</span>, <span class="dt">priors =</span> <span class="ot">TRUE</span>)
<span class="kw">print</span>(model_summary)</code></pre></div>
<pre><code>## Family: hurdle_poisson(log)
## Formula: children ~ paternalage + birth_cohort + male + maternalage.factor + paternal_loss + maternal_loss + older_siblings + nr.siblings + last_born
## hu ~ paternalage + birth_cohort + male + maternalage.factor + paternal_loss + maternal_loss + older_siblings + nr.siblings + last_born
## Data: model_data (Number of observations: 68724)
## Samples: 6 chains, each with iter = 800; warmup = 300; thin = 1;
## total post-warmup samples = 3000
## ICs: LOO = Not computed; WAIC = Not computed
##
## Priors:
## b ~ normal(0,5)
## b_hu ~ normal(0,5)
##
## Population-Level Effects:
## Estimate Est.Error l-95% CI u-95% CI Eff.Sample
## Intercept 2.14 0.02 2.10 2.17 874
## paternalage -0.02 0.00 -0.02 -0.01 3000
## birth_cohort1675M1680 0.01 0.01 -0.02 0.04 690
## birth_cohort1680M1685 0.03 0.01 0.01 0.06 679
## birth_cohort1685M1690 0.04 0.01 0.01 0.07 650
## birth_cohort1690M1695 0.03 0.01 0.01 0.06 595
## birth_cohort1695M1700 0.03 0.01 0.00 0.05 589
## birth_cohort1700M1705 0.01 0.01 -0.01 0.03 562
## birth_cohort1705M1710 -0.01 0.01 -0.03 0.02 557
## birth_cohort1710M1715 -0.01 0.01 -0.04 0.01 542
## birth_cohort1715M1720 -0.04 0.01 -0.07 -0.02 535
## birth_cohort1720M1725 -0.04 0.01 -0.06 -0.02 510
## birth_cohort1725M1730 -0.07 0.01 -0.09 -0.04 528
## birth_cohort1730M1735 -0.05 0.01 -0.07 -0.02 531
## birth_cohort1735M1740 -0.06 0.01 -0.08 -0.03 513
## male1 0.11 0.00 0.10 0.12 3000
## maternalage.factor1420 -0.01 0.01 -0.02 0.01 3000
## maternalage.factor3550 0.01 0.01 0.00 0.02 3000
## paternal_loss01 -0.01 0.02 -0.04 0.03 2154
## paternal_loss15 0.00 0.01 -0.02 0.02 1736
## paternal_loss510 0.00 0.01 -0.02 0.02 1931
## paternal_loss1015 -0.01 0.01 -0.03 0.00 1663
## paternal_loss1520 -0.02 0.01 -0.04 -0.01 1913
## paternal_loss2025 -0.02 0.01 -0.04 -0.01 1685
## paternal_loss2530 -0.01 0.01 -0.03 0.00 1732
## paternal_loss3035 -0.02 0.01 -0.04 -0.01 1608
## paternal_loss3540 -0.02 0.01 -0.04 -0.01 1696
## paternal_loss4045 0.00 0.01 -0.02 0.01 1926
## paternal_lossunclear -0.04 0.01 -0.05 -0.03 1557
## maternal_loss01 -0.03 0.02 -0.07 0.01 2724
## maternal_loss15 -0.02 0.01 -0.04 0.01 3000
## maternal_loss510 0.01 0.01 -0.01 0.02 3000
## maternal_loss1015 -0.01 0.01 -0.03 0.01 3000
## maternal_loss1520 0.00 0.01 -0.02 0.02 3000
## maternal_loss2025 -0.03 0.01 -0.04 -0.01 3000
## maternal_loss2530 -0.02 0.01 -0.04 -0.01 3000
## maternal_loss3035 -0.02 0.01 -0.03 0.00 3000
## maternal_loss3540 -0.01 0.01 -0.02 0.00 3000
## maternal_loss4045 0.00 0.01 -0.02 0.01 3000
## maternal_lossunclear -0.02 0.01 -0.04 -0.01 3000
## older_siblings1 -0.02 0.01 -0.03 0.00 3000
## older_siblings2 -0.01 0.01 -0.03 0.00 2020
## older_siblings3 -0.02 0.01 -0.04 -0.01 2067
## older_siblings4 0.00 0.01 -0.02 0.01 1965
## older_siblings5P -0.01 0.01 -0.03 0.00 1731
## nr.siblings 0.01 0.00 0.01 0.01 2459
## last_born1 0.01 0.01 -0.01 0.02 3000
## hu_Intercept -0.87 0.07 -1.00 -0.73 431
## hu_paternalage 0.00 0.01 -0.03 0.02 1759
## hu_birth_cohort1675M1680 0.06 0.06 -0.06 0.19 561
## hu_birth_cohort1680M1685 0.20 0.06 0.08 0.32 540
## hu_birth_cohort1685M1690 0.30 0.06 0.17 0.43 573
## hu_birth_cohort1690M1695 0.08 0.06 -0.04 0.19 481
## hu_birth_cohort1695M1700 0.10 0.06 -0.02 0.21 465
## hu_birth_cohort1700M1705 0.23 0.06 0.12 0.33 461
## hu_birth_cohort1705M1710 0.14 0.06 0.03 0.25 427
## hu_birth_cohort1710M1715 0.39 0.05 0.28 0.50 367
## hu_birth_cohort1715M1720 0.28 0.05 0.18 0.38 437
## hu_birth_cohort1720M1725 0.30 0.05 0.20 0.40 420
## hu_birth_cohort1725M1730 0.63 0.05 0.53 0.74 326
## hu_birth_cohort1730M1735 0.68 0.05 0.59 0.78 332
## hu_birth_cohort1735M1740 0.53 0.05 0.43 0.62 397
## hu_male1 0.40 0.02 0.37 0.43 2748
## hu_maternalage.factor1420 0.00 0.03 -0.07 0.06 1348
## hu_maternalage.factor3550 0.07 0.02 0.02 0.11 1745
## hu_paternal_loss01 0.59 0.07 0.47 0.72 1651
## hu_paternal_loss15 0.33 0.05 0.24 0.43 1211
## hu_paternal_loss510 0.32 0.04 0.24 0.40 1147
## hu_paternal_loss1015 0.19 0.04 0.12 0.27 1164
## hu_paternal_loss1520 0.28 0.04 0.21 0.35 1080
## hu_paternal_loss2025 0.18 0.03 0.12 0.25 1120
## hu_paternal_loss2530 0.18 0.03 0.12 0.25 1137
## hu_paternal_loss3035 0.14 0.03 0.08 0.20 1128
## hu_paternal_loss3540 0.10 0.03 0.04 0.16 1143
## hu_paternal_loss4045 0.06 0.04 -0.01 0.13 1273
## hu_paternal_lossunclear 0.35 0.03 0.29 0.41 919
## hu_maternal_loss01 1.04 0.07 0.91 1.18 2375
## hu_maternal_loss15 0.42 0.04 0.34 0.50 1830
## hu_maternal_loss510 0.29 0.04 0.22 0.36 2149
## hu_maternal_loss1015 0.26 0.04 0.19 0.34 1952
## hu_maternal_loss1520 0.20 0.04 0.12 0.27 1960
## hu_maternal_loss2025 0.16 0.03 0.10 0.23 1892
## hu_maternal_loss2530 0.07 0.03 0.00 0.13 1760
## hu_maternal_loss3035 0.09 0.03 0.03 0.14 1797
## hu_maternal_loss3540 0.08 0.03 0.02 0.14 2160
## hu_maternal_loss4045 0.00 0.03 -0.05 0.06 1979
## hu_maternal_lossunclear 0.19 0.03 0.14 0.25 1672
## hu_older_siblings1 -0.05 0.03 -0.10 0.01 1246
## hu_older_siblings2 -0.08 0.03 -0.13 -0.01 1212
## hu_older_siblings3 -0.11 0.03 -0.18 -0.05 1200
## hu_older_siblings4 -0.12 0.03 -0.18 -0.05 1196
## hu_older_siblings5P -0.15 0.03 -0.21 -0.09 1014
## hu_nr.siblings 0.02 0.00 0.01 0.02 2021
## hu_last_born1 0.02 0.03 -0.03 0.08 2115
## Rhat
## Intercept 1.00
## paternalage 1.00
## birth_cohort1675M1680 1.00
## birth_cohort1680M1685 1.00
## birth_cohort1685M1690 1.00
## birth_cohort1690M1695 1.01
## birth_cohort1695M1700 1.00
## birth_cohort1700M1705 1.00
## birth_cohort1705M1710 1.01
## birth_cohort1710M1715 1.01
## birth_cohort1715M1720 1.00
## birth_cohort1720M1725 1.00
## birth_cohort1725M1730 1.01
## birth_cohort1730M1735 1.00
## birth_cohort1735M1740 1.00
## male1 1.00
## maternalage.factor1420 1.00
## maternalage.factor3550 1.00
## paternal_loss01 1.00
## paternal_loss15 1.00
## paternal_loss510 1.00
## paternal_loss1015 1.00
## paternal_loss1520 1.00
## paternal_loss2025 1.00
## paternal_loss2530 1.00
## paternal_loss3035 1.00
## paternal_loss3540 1.00
## paternal_loss4045 1.00
## paternal_lossunclear 1.00
## maternal_loss01 1.00
## maternal_loss15 1.00
## maternal_loss510 1.00
## maternal_loss1015 1.00
## maternal_loss1520 1.00
## maternal_loss2025 1.00
## maternal_loss2530 1.00
## maternal_loss3035 1.00
## maternal_loss3540 1.00
## maternal_loss4045 1.00
## maternal_lossunclear 1.00
## older_siblings1 1.00
## older_siblings2 1.00
## older_siblings3 1.00
## older_siblings4 1.00
## older_siblings5P 1.00
## nr.siblings 1.00
## last_born1 1.00
## hu_Intercept 1.01
## hu_paternalage 1.00
## hu_birth_cohort1675M1680 1.01
## hu_birth_cohort1680M1685 1.02
## hu_birth_cohort1685M1690 1.01
## hu_birth_cohort1690M1695 1.02
## hu_birth_cohort1695M1700 1.01
## hu_birth_cohort1700M1705 1.01
## hu_birth_cohort1705M1710 1.02
## hu_birth_cohort1710M1715 1.02
## hu_birth_cohort1715M1720 1.02
## hu_birth_cohort1720M1725 1.02
## hu_birth_cohort1725M1730 1.02
## hu_birth_cohort1730M1735 1.02
## hu_birth_cohort1735M1740 1.02
## hu_male1 1.00
## hu_maternalage.factor1420 1.00
## hu_maternalage.factor3550 1.00
## hu_paternal_loss01 1.00
## hu_paternal_loss15 1.00
## hu_paternal_loss510 1.01
## hu_paternal_loss1015 1.00
## hu_paternal_loss1520 1.00
## hu_paternal_loss2025 1.00
## hu_paternal_loss2530 1.00
## hu_paternal_loss3035 1.00
## hu_paternal_loss3540 1.00
## hu_paternal_loss4045 1.00
## hu_paternal_lossunclear 1.00
## hu_maternal_loss01 1.00
## hu_maternal_loss15 1.00
## hu_maternal_loss510 1.00
## hu_maternal_loss1015 1.00
## hu_maternal_loss1520 1.01
## hu_maternal_loss2025 1.00
## hu_maternal_loss2530 1.00
## hu_maternal_loss3035 1.00
## hu_maternal_loss3540 1.00
## hu_maternal_loss4045 1.00
## hu_maternal_lossunclear 1.00
## hu_older_siblings1 1.00
## hu_older_siblings2 1.00
## hu_older_siblings3 1.00
## hu_older_siblings4 1.00
## hu_older_siblings5P 1.00
## hu_nr.siblings 1.00
## hu_last_born1 1.00
##
## Samples were drawn using sampling(NUTS). For each parameter, Eff.Sample
## is a crude measure of effective sample size, and Rhat is the potential
## scale reduction factor on split chains (at convergence, Rhat = 1).</code></pre>
</div>
<div id="table-of-fixed-effects" class="section level4">
<h4>Table of fixed effects</h4>
<p>Estimates are <code>exp(b)</code>. When they are referring to the hurdle (hu) component, or a dichotomous outcome, they are odds ratios, when they are referring to a Poisson component, they are hazard ratios. In both cases, they are presented with 95% credibility intervals. To see the effects on the response scale (probability or number of children), consult the marginal effect plots.</p>
<div class="sourceCode"><pre class="sourceCode r"><code class="sourceCode r">fixed_eff =<span class="st"> </span><span class="kw">data.frame</span>(model_summary$fixed, <span class="dt">check.names =</span> F)
fixed_eff$Est.Error =<span class="st"> </span>fixed_eff$Eff.Sample =<span class="st"> </span>fixed_eff$Rhat =<span class="st"> </span><span class="ot">NULL</span>
fixed_eff$<span class="st">`</span><span class="dt">Odds/hazard ratio</span><span class="st">`</span> =<span class="st"> </span><span class="kw">exp</span>(fixed_eff$Estimate)
fixed_eff$<span class="st">`</span><span class="dt">OR/HR low 95%</span><span class="st">`</span> =<span class="st"> </span><span class="kw">exp</span>(fixed_eff$<span class="st">`</span><span class="dt">l-95% CI</span><span class="st">`</span>)
fixed_eff$<span class="st">`</span><span class="dt">OR/HR high 95%</span><span class="st">`</span> =<span class="st"> </span><span class="kw">exp</span>(fixed_eff$<span class="st">`</span><span class="dt">u-95% CI</span><span class="st">`</span>)
fixed_eff =<span class="st"> </span>fixed_eff %>%<span class="st"> </span><span class="kw">select</span>(<span class="st">`</span><span class="dt">Odds/hazard ratio</span><span class="st">`</span>, <span class="st">`</span><span class="dt">OR/HR low 95%</span><span class="st">`</span>, <span class="st">`</span><span class="dt">OR/HR high 95%</span><span class="st">`</span>)
pander::<span class="kw">pander</span>(fixed_eff)</code></pre></div>
<table>
<colgroup>
<col width="38%" />
<col width="23%" />
<col width="19%" />
<col width="19%" />
</colgroup>
<thead>
<tr class="header">
<th align="center"> </th>
<th align="center">Odds/hazard ratio</th>
<th align="center">OR/HR low 95%</th>
<th align="center">OR/HR high 95%</th>
</tr>
</thead>
<tbody>
<tr class="odd">
<td align="center"><strong>Intercept</strong></td>
<td align="center">8.468</td>
<td align="center">8.199</td>
<td align="center">8.748</td>
</tr>
<tr class="even">
<td align="center"><strong>paternalage</strong></td>
<td align="center">0.9841</td>
<td align="center">0.9784</td>
<td align="center">0.9902</td>
</tr>
<tr class="odd">
<td align="center"><strong>birth_cohort1675M1680</strong></td>
<td align="center">1.013</td>
<td align="center">0.9846</td>
<td align="center">1.042</td>
</tr>
<tr class="even">
<td align="center"><strong>birth_cohort1680M1685</strong></td>
<td align="center">1.035</td>
<td align="center">1.006</td>
<td align="center">1.063</td>
</tr>
<tr class="odd">
<td align="center"><strong>birth_cohort1685M1690</strong></td>
<td align="center">1.041</td>
<td align="center">1.012</td>
<td align="center">1.07</td>
</tr>
<tr class="even">
<td align="center"><strong>birth_cohort1690M1695</strong></td>
<td align="center">1.034</td>
<td align="center">1.007</td>
<td align="center">1.061</td>
</tr>
<tr class="odd">
<td align="center"><strong>birth_cohort1695M1700</strong></td>
<td align="center">1.026</td>
<td align="center">0.9987</td>
<td align="center">1.052</td>
</tr>
<tr class="even">
<td align="center"><strong>birth_cohort1700M1705</strong></td>
<td align="center">1.011</td>
<td align="center">0.9858</td>
<td align="center">1.035</td>
</tr>
<tr class="odd">
<td align="center"><strong>birth_cohort1705M1710</strong></td>
<td align="center">0.9936</td>
<td align="center">0.9689</td>
<td align="center">1.018</td>
</tr>
<tr class="even">
<td align="center"><strong>birth_cohort1710M1715</strong></td>
<td align="center">0.9899</td>
<td align="center">0.9648</td>
<td align="center">1.014</td>
</tr>
<tr class="odd">
<td align="center"><strong>birth_cohort1715M1720</strong></td>
<td align="center">0.9584</td>
<td align="center">0.9349</td>
<td align="center">0.9823</td>
</tr>
<tr class="even">
<td align="center"><strong>birth_cohort1720M1725</strong></td>
<td align="center">0.961</td>
<td align="center">0.9377</td>
<td align="center">0.9837</td>
</tr>
<tr class="odd">
<td align="center"><strong>birth_cohort1725M1730</strong></td>
<td align="center">0.9352</td>
<td align="center">0.9133</td>
<td align="center">0.9568</td>
</tr>
<tr class="even">
<td align="center"><strong>birth_cohort1730M1735</strong></td>
<td align="center">0.9552</td>
<td align="center">0.9326</td>
<td align="center">0.9777</td>
</tr>
<tr class="odd">
<td align="center"><strong>birth_cohort1735M1740</strong></td>
<td align="center">0.9459</td>
<td align="center">0.9242</td>
<td align="center">0.968</td>
</tr>
<tr class="even">
<td align="center"><strong>male1</strong></td>
<td align="center">1.117</td>
<td align="center">1.109</td>
<td align="center">1.126</td>
</tr>
<tr class="odd">
<td align="center"><strong>maternalage.factor1420</strong></td>
<td align="center">0.995</td>
<td align="center">0.9792</td>
<td align="center">1.011</td>
</tr>
<tr class="even">
<td align="center"><strong>maternalage.factor3550</strong></td>
<td align="center">1.013</td>
<td align="center">1.001</td>
<td align="center">1.025</td>
</tr>
<tr class="odd">
<td align="center"><strong>paternal_loss01</strong></td>
<td align="center">0.9942</td>
<td align="center">0.9606</td>
<td align="center">1.028</td>
</tr>
<tr class="even">
<td align="center"><strong>paternal_loss15</strong></td>
<td align="center">1</td>
<td align="center">0.9772</td>
<td align="center">1.023</td>
</tr>
<tr class="odd">
<td align="center"><strong>paternal_loss510</strong></td>
<td align="center">0.9974</td>
<td align="center">0.9775</td>
<td align="center">1.016</td>
</tr>
<tr class="even">
<td align="center"><strong>paternal_loss1015</strong></td>
<td align="center">0.9867</td>
<td align="center">0.9698</td>
<td align="center">1.004</td>
</tr>
<tr class="odd">
<td align="center"><strong>paternal_loss1520</strong></td>
<td align="center">0.9763</td>
<td align="center">0.9593</td>
<td align="center">0.9929</td>
</tr>
<tr class="even">
<td align="center"><strong>paternal_loss2025</strong></td>
<td align="center">0.9785</td>
<td align="center">0.9626</td>
<td align="center">0.994</td>
</tr>
<tr class="odd">
<td align="center"><strong>paternal_loss2530</strong></td>
<td align="center">0.9879</td>
<td align="center">0.9725</td>
<td align="center">1.003</td>
</tr>
<tr class="even">
<td align="center"><strong>paternal_loss3035</strong></td>
<td align="center">0.9764</td>
<td align="center">0.9622</td>
<td align="center">0.9917</td>
</tr>
<tr class="odd">
<td align="center"><strong>paternal_loss3540</strong></td>
<td align="center">0.9784</td>
<td align="center">0.9637</td>
<td align="center">0.993</td>
</tr>
<tr class="even">
<td align="center"><strong>paternal_loss4045</strong></td>
<td align="center">0.9973</td>
<td align="center">0.9812</td>
<td align="center">1.014</td>
</tr>
<tr class="odd">
<td align="center"><strong>paternal_lossunclear</strong></td>
<td align="center">0.9609</td>
<td align="center">0.9471</td>
<td align="center">0.9751</td>
</tr>
<tr class="even">
<td align="center"><strong>maternal_loss01</strong></td>
<td align="center">0.9695</td>
<td align="center">0.9342</td>
<td align="center">1.007</td>
</tr>
<tr class="odd">
<td align="center"><strong>maternal_loss15</strong></td>
<td align="center">0.9831</td>
<td align="center">0.9618</td>
<td align="center">1.005</td>
</tr>
<tr class="even">
<td align="center"><strong>maternal_loss510</strong></td>
<td align="center">1.006</td>
<td align="center">0.9873</td>
<td align="center">1.024</td>
</tr>
<tr class="odd">
<td align="center"><strong>maternal_loss1015</strong></td>
<td align="center">0.9899</td>
<td align="center">0.9716</td>
<td align="center">1.008</td>
</tr>
<tr class="even">
<td align="center"><strong>maternal_loss1520</strong></td>
<td align="center">0.9982</td>
<td align="center">0.9809</td>
<td align="center">1.016</td>
</tr>
<tr class="odd">
<td align="center"><strong>maternal_loss2025</strong></td>
<td align="center">0.9723</td>
<td align="center">0.9563</td>
<td align="center">0.9887</td>
</tr>
<tr class="even">
<td align="center"><strong>maternal_loss2530</strong></td>
<td align="center">0.9759</td>
<td align="center">0.9607</td>
<td align="center">0.9911</td>
</tr>
<tr class="odd">
<td align="center"><strong>maternal_loss3035</strong></td>
<td align="center">0.9826</td>
<td align="center">0.9678</td>
<td align="center">0.997</td>
</tr>
<tr class="even">
<td align="center"><strong>maternal_loss3540</strong></td>
<td align="center">0.9892</td>
<td align="center">0.9764</td>
<td align="center">1.003</td>
</tr>
<tr class="odd">
<td align="center"><strong>maternal_loss4045</strong></td>
<td align="center">0.9987</td>
<td align="center">0.9843</td>
<td align="center">1.014</td>
</tr>
<tr class="even">
<td align="center"><strong>maternal_lossunclear</strong></td>
<td align="center">0.9758</td>
<td align="center">0.9625</td>
<td align="center">0.9894</td>
</tr>
<tr class="odd">
<td align="center"><strong>older_siblings1</strong></td>
<td align="center">0.9828</td>
<td align="center">0.9698</td>
<td align="center">0.9962</td>
</tr>
<tr class="even">
<td align="center"><strong>older_siblings2</strong></td>
<td align="center">0.9855</td>
<td align="center">0.9708</td>
<td align="center">0.9995</td>
</tr>
<tr class="odd">
<td align="center"><strong>older_siblings3</strong></td>
<td align="center">0.9796</td>
<td align="center">0.9642</td>
<td align="center">0.9938</td>
</tr>
<tr class="even">
<td align="center"><strong>older_siblings4</strong></td>
<td align="center">0.9964</td>
<td align="center">0.9801</td>
<td align="center">1.013</td>
</tr>
<tr class="odd">
<td align="center"><strong>older_siblings5P</strong></td>
<td align="center">0.9886</td>
<td align="center">0.9738</td>
<td align="center">1.004</td>
</tr>
<tr class="even">
<td align="center"><strong>nr.siblings</strong></td>
<td align="center">1.007</td>
<td align="center">1.005</td>
<td align="center">1.008</td>
</tr>
<tr class="odd">
<td align="center"><strong>last_born1</strong></td>
<td align="center">1.007</td>
<td align="center">0.9933</td>
<td align="center">1.021</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_Intercept</strong></td>
<td align="center">0.4195</td>
<td align="center">0.3673</td>
<td align="center">0.4818</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_paternalage</strong></td>
<td align="center">0.999</td>
<td align="center">0.974</td>
<td align="center">1.024</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_birth_cohort1675M1680</strong></td>
<td align="center">1.067</td>
<td align="center">0.9402</td>
<td align="center">1.21</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_birth_cohort1680M1685</strong></td>
<td align="center">1.224</td>
<td align="center">1.085</td>
<td align="center">1.381</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_birth_cohort1685M1690</strong></td>
<td align="center">1.349</td>
<td align="center">1.189</td>
<td align="center">1.531</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_birth_cohort1690M1695</strong></td>
<td align="center">1.083</td>
<td align="center">0.9587</td>
<td align="center">1.212</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_birth_cohort1695M1700</strong></td>
<td align="center">1.102</td>
<td align="center">0.9846</td>
<td align="center">1.231</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_birth_cohort1700M1705</strong></td>
<td align="center">1.256</td>
<td align="center">1.129</td>
<td align="center">1.397</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_birth_cohort1705M1710</strong></td>
<td align="center">1.153</td>
<td align="center">1.034</td>
<td align="center">1.282</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_birth_cohort1710M1715</strong></td>
<td align="center">1.478</td>
<td align="center">1.329</td>
<td align="center">1.643</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_birth_cohort1715M1720</strong></td>
<td align="center">1.324</td>
<td align="center">1.193</td>
<td align="center">1.468</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_birth_cohort1720M1725</strong></td>
<td align="center">1.352</td>
<td align="center">1.222</td>
<td align="center">1.496</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_birth_cohort1725M1730</strong></td>
<td align="center">1.886</td>
<td align="center">1.704</td>
<td align="center">2.091</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_birth_cohort1730M1735</strong></td>
<td align="center">1.979</td>
<td align="center">1.798</td>
<td align="center">2.183</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_birth_cohort1735M1740</strong></td>
<td align="center">1.695</td>
<td align="center">1.538</td>
<td align="center">1.865</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_male1</strong></td>
<td align="center">1.494</td>
<td align="center">1.451</td>
<td align="center">1.539</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_maternalage.factor1420</strong></td>
<td align="center">0.9983</td>
<td align="center">0.9346</td>
<td align="center">1.064</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_maternalage.factor3550</strong></td>
<td align="center">1.07</td>
<td align="center">1.023</td>
<td align="center">1.118</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_paternal_loss01</strong></td>
<td align="center">1.81</td>
<td align="center">1.593</td>
<td align="center">2.055</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_paternal_loss15</strong></td>
<td align="center">1.396</td>
<td align="center">1.271</td>
<td align="center">1.532</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_paternal_loss510</strong></td>
<td align="center">1.374</td>
<td align="center">1.274</td>
<td align="center">1.489</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_paternal_loss1015</strong></td>
<td align="center">1.211</td>
<td align="center">1.125</td>
<td align="center">1.307</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_paternal_loss1520</strong></td>
<td align="center">1.317</td>
<td align="center">1.233</td>
<td align="center">1.415</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_paternal_loss2025</strong></td>
<td align="center">1.199</td>
<td align="center">1.124</td>
<td align="center">1.28</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_paternal_loss2530</strong></td>
<td align="center">1.201</td>
<td align="center">1.126</td>
<td align="center">1.28</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_paternal_loss3035</strong></td>
<td align="center">1.149</td>
<td align="center">1.081</td>
<td align="center">1.224</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_paternal_loss3540</strong></td>
<td align="center">1.108</td>
<td align="center">1.043</td>
<td align="center">1.177</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_paternal_loss4045</strong></td>
<td align="center">1.065</td>
<td align="center">0.9938</td>
<td align="center">1.144</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_paternal_lossunclear</strong></td>
<td align="center">1.42</td>
<td align="center">1.337</td>
<td align="center">1.514</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_maternal_loss01</strong></td>
<td align="center">2.842</td>
<td align="center">2.496</td>
<td align="center">3.242</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_maternal_loss15</strong></td>
<td align="center">1.521</td>
<td align="center">1.408</td>
<td align="center">1.648</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_maternal_loss510</strong></td>
<td align="center">1.339</td>
<td align="center">1.247</td>
<td align="center">1.44</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_maternal_loss1015</strong></td>
<td align="center">1.303</td>
<td align="center">1.213</td>
<td align="center">1.403</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_maternal_loss1520</strong></td>
<td align="center">1.218</td>
<td align="center">1.132</td>
<td align="center">1.305</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_maternal_loss2025</strong></td>
<td align="center">1.178</td>
<td align="center">1.103</td>
<td align="center">1.256</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_maternal_loss2530</strong></td>
<td align="center">1.068</td>
<td align="center">1.002</td>
<td align="center">1.139</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_maternal_loss3035</strong></td>
<td align="center">1.089</td>
<td align="center">1.03</td>
<td align="center">1.154</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_maternal_loss3540</strong></td>
<td align="center">1.085</td>
<td align="center">1.024</td>
<td align="center">1.146</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_maternal_loss4045</strong></td>
<td align="center">1.004</td>
<td align="center">0.9468</td>
<td align="center">1.064</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_maternal_lossunclear</strong></td>
<td align="center">1.215</td>
<td align="center">1.148</td>
<td align="center">1.282</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_older_siblings1</strong></td>
<td align="center">0.9548</td>
<td align="center">0.9025</td>
<td align="center">1.009</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_older_siblings2</strong></td>
<td align="center">0.9275</td>
<td align="center">0.8747</td>
<td align="center">0.9856</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_older_siblings3</strong></td>
<td align="center">0.8935</td>
<td align="center">0.839</td>
<td align="center">0.9497</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_older_siblings4</strong></td>
<td align="center">0.89</td>
<td align="center">0.8342</td>
<td align="center">0.9541</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_older_siblings5P</strong></td>
<td align="center">0.8628</td>
<td align="center">0.8104</td>
<td align="center">0.9183</td>
</tr>
<tr class="odd">
<td align="center"><strong>hu_nr.siblings</strong></td>
<td align="center">1.017</td>
<td align="center">1.011</td>
<td align="center">1.022</td>
</tr>
<tr class="even">
<td align="center"><strong>hu_last_born1</strong></td>
<td align="center">1.025</td>
<td align="center">0.9708</td>
<td align="center">1.085</td>
</tr>
</tbody>
</table>
</div>
</div>
<div id="paternal-age-effect" class="section level3">
<h3>Paternal age effect</h3>
<div class="sourceCode"><pre class="sourceCode r"><code class="sourceCode r">pander::<span class="kw">pander</span>(<span class="kw">paternal_age_10y_effect</span>(model))</code></pre></div>
<table style="width:92%;">
<colgroup>
<col width="27%" />
<col width="25%" />
<col width="19%" />
<col width="19%" />
</colgroup>
<thead>
<tr class="header">
<th align="center">effect</th>
<th align="center">median_estimate</th>
<th align="center">ci_95</th>
<th align="center">ci_80</th>
</tr>
</thead>
<tbody>
<tr class="odd">
<td align="center">estimate father 25y</td>
<td align="center">5.82</td>
<td align="center">[5.57;6.06]</td>
<td align="center">[5.65;5.98]</td>
</tr>
<tr class="even">
<td align="center">estimate father 35y</td>
<td align="center">5.73</td>
<td align="center">[5.48;5.97]</td>
<td align="center">[5.56;5.89]</td>
</tr>
<tr class="odd">
<td align="center">percentage change</td>
<td align="center">-1.57</td>
<td align="center">[-2.51;-0.59]</td>
<td align="center">[-2.17;-0.90]</td>
</tr>
<tr class="even">
<td align="center">OR/IRR</td>
<td align="center">0.98</td>
<td align="center">[0.98;0.99]</td>
<td align="center">[0.98;0.99]</td>
</tr>
<tr class="odd">
<td align="center">OR hurdle</td>
<td align="center">1.00</td>
<td align="center">[0.97;1.02]</td>
<td align="center">[0.98;1.01]</td>
</tr>
</tbody>
</table>
</div>