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Different results compared to PrankWeb? #70

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AlexLam37 opened this issue Apr 5, 2024 · 1 comment
Open

Different results compared to PrankWeb? #70

AlexLam37 opened this issue Apr 5, 2024 · 1 comment

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@AlexLam37
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This is the same/related issue I've previously asked in the prankweb page however I thought it was useful to ask here as well.
cusbg/prankweb#142 (comment)

I am trying to use p2rank to predict pockets for a bunch of proteins but I noticed there are different results compared to the web server. I.e. if I go to the web server and use the "predicted structure" and input a uniprot ID, it seemingly gives different results compared to if I download the AF model from uniprot, and then run that on p2rank.

Similarly if I download the AF model and submit as custom structure to the web server, it gives same result as the standalone p2rank.

Is the web server over/underestimating pocket probabilities? Please see below for an example using A0A644EZV9

Using "predicted structure" on prankweb
image

Using "custom structure" on prankweb, same results as running standalone p2rank
image

@davidhoksza
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See the explanation at cusbg/prankweb#142 (comment) .

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