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Describe the problem
PROTACs are a class of therapeutics that flag target proteins to a cell's waste disposal system, instead of the traditional binding to targets. It has been very promising due to its ability to tackle undruggable targets. However, problems still exist, such as designing the PROTACs, measure the degradability, understand the mechanism. A recent paper https://www.biorxiv.org/content/10.1101/2021.09.27.462040v1 has a nice dataset that predicts degradability given a proten PDB. The dataset is linked here: http://mapd.cistrome.org/
Describe the problem
PROTACs are a class of therapeutics that flag target proteins to a cell's waste disposal system, instead of the traditional binding to targets. It has been very promising due to its ability to tackle undruggable targets. However, problems still exist, such as designing the PROTACs, measure the degradability, understand the mechanism. A recent paper https://www.biorxiv.org/content/10.1101/2021.09.27.462040v1 has a nice dataset that predicts degradability given a proten PDB. The dataset is linked here: http://mapd.cistrome.org/
Describe the solution you'd like
Additional context
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