Large >270Mb contigs vs >14Gb reference

[Ural-Yunusbaev]

Hey there,

I am trying to align >14Gb allopolyploid wheat genome assembly contigs (N50>30Mb, longest>270Mb) to a >14Gb reference (longest chromosome>850Mb) with the following parameters:
ragtag.py scaffold --mm2-params '-x asm5 -t '${cpu}' -I 16G' -t ${cpu} reference.fasta contigs.fasta
in a node with 400Gb memory.

After 4 hours I am getting the following error:
Wed Apr 12 16:06:48 2023 --- INFO: Running: minimap2 -x asm5 -t 15 -I 16G /dev/shm/ragtag/reference.fasta /dev/shm/ragtag/contigs.fasta > /dev/shm/ragtag/ragtag_output/ragtag.scaffold.asm.paf 2> /dev/shm/ragtag/ragtag_output/ragtag.scaffold.asm.paf.log
Traceback (most recent call last):
File "/homes/user/.local/bin/ragtag_scaffold.py", line 4, in
import('pkg_resources').run_script('RagTag==2.1.0', 'ragtag_scaffold.py')
File "/homes/user/.local/lib/python3.7/site-packages/pkg_resources/init.py", line 656, in run_script
self.require(requires)[0].run_script(script_name, ns)
File "/homes/user/.local/lib/python3.7/site-packages/pkg_resources/init.py", line 1460, in run_script
exec(script_code, namespace, namespace)
File "/homes/user/.local/lib/python3.7/site-packages/RagTag-2.1.0-py3.7.egg/EGG-INFO/scripts/ragtag_scaffold.py", line 577, in
File "/homes/user/.local/lib/python3.7/site-packages/RagTag-2.1.0-py3.7.egg/EGG-INFO/scripts/ragtag_scaffold.py", line 420, in main
File "/homes/user/.local/lib/python3.7/site-packages/RagTag-2.1.0-py3.7.egg/ragtag_utilities/Aligner.py", line 128, in run_aligner
File "/homes/user/.local/lib/python3.7/site-packages/RagTag-2.1.0-py3.7.egg/ragtag_utilities/utilities.py", line 73, in run_oe
RuntimeError: Failed : minimap2 -x asm5 -t 15 -I 16G /dev/shm/ragtag/reference.fasta /dev/shm/ragtag/contigs.fasta > /dev/shm/ragtag/ragtag_output/ragtag.scaffold.asm.paf 2> /dev/shm/ragtag/ragtag_output/ragtag.scaffold.asm.paf.log

ragtag.py -v
v2.1.0

seff output:
Nodes: 1
Cores per node: 16
CPU Utilized: 09:11:30
CPU Efficiency: 14.96% of 2-13:26:08 core-walltime
Job Wall-clock time: 03:50:23
Memory Utilized: 278.09 GB
Memory Efficiency: 69.52% of 400.00 GB

When I broke apart all the contigs >75Mb and it reran, the same minimap2 command worked perfectly.
What is the reason? How can I go with contigs longer than 75Mb?
Thank you.