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XBB.1 misclassified as XBB in Singapore in samples after 2022-10-10 #49

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mg14 opened this issue Oct 25, 2022 · 0 comments
Open

XBB.1 misclassified as XBB in Singapore in samples after 2022-10-10 #49

mg14 opened this issue Oct 25, 2022 · 0 comments

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@mg14
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mg14 commented Oct 25, 2022

Hi

A recent batch of genomes from Singapore has been classified as XBB even though they appear to have the lineage defining variants S:G252V and ORF8:G8*:

image

https://cov-spectrum.org/explore/Singapore/AllSamples/from=2022-09-15&to=2022-10-17/variants?pangoLineage=XBB&

I believe it's scorpio related, as Nextclade classifies most of them correctly:

image

https://cov-spectrum.org/explore/Singapore/AllSamples/from=2022-09-15&to=2022-10-17/variants?nextcladePangoLineage=XBB&

I don't have access to the raw genomes - possibly also brought about by some contamination or other sequencing issue - but worth keeping an eye on, because at face value it appears as if XBB is replacing XBB.1.

Moritz

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