Open-CRAVAT is a python package that performs genomic variant interpretation including variant impact, annotation, and scoring. It has a modular architecture with a wide variety of analysis modules that are developed both by the CRAVAT team and the broader variant analysis community. Open-CRAVAT is a product of the Karchin Lab at Johns Hopkins University with funding provided by the National Cancer Institute's ITCR program.
Please see: Open-CRAVAT Docs for installation instructions and software documentation.